Screen LibraryPerfusion cell culture processes for biopharmaceuticals : process development, design, and scale-up /
This book is a monography about perfusion cell cultures for the production of biopharmaceuticals, such as therapeutic proteins (i.e. biomolecules like monoclonal antibodies), and describes the fundamentals, design and operation of these processes. Context is given in the first chapters to understand...
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| Main Authors: | |
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| Group Author: | ; |
| Published: |
Cambridge University Press,
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| Publisher Address: | Cambridge, UK : |
| Publication Dates: | 2020. |
| Literature type: | Book |
| Language: | English |
| Series: |
Cambridge series in chemical engineering
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| Subjects: | |
| Summary: |
This book is a monography about perfusion cell cultures for the production of biopharmaceuticals, such as therapeutic proteins (i.e. biomolecules like monoclonal antibodies), and describes the fundamentals, design and operation of these processes. Context is given in the first chapters to understand the state-of-the-art of the technology. We then give an overview of the challenges and objectives in operating mammalian cell perfusion cultures and provide guidelines for the design and setup of lab-scale bioreactor systems, and the required control structure to achieve stable operation. Scale-down devices and PAT tools are described in the context of continuous manufacturing and guidelines for process optimization are given using a variety of case studies to illustrate different approaches. Scale-up is also adressed with a strong focus on bioreactor aeration and mixing, shear stress and cell retention device. Finally, a general introduction for the application of mechanistic and statistic models in bioreactor process development and optimization is given in the last chapter. |
| Carrier Form: | xv, 202 pages : illustrations (some color), forms ; 25 cm. |
| Bibliography: | Includes bibliographical references (pages 174-197) and index. |
| ISBN: |
9781108480031 1108480039 |
| Index Number: | RM301 |
| CLC: | Q813.1 |
| Call Number: | Q813.1/W854 |
| Contents: | Perfusion mammalian cell culture for recombinant protein manufacturing -- Perfusion bioreactors : the set up and process characterization -- Scale-down models and sensors for process development -- Design and optimization of mammalian cell perfusion cultures -- Clinical and commercial scale reactors -- Mechanistic and statistical modeling of bioprocesses. |