Screen LibraryDNA-targeting molecules as therapeutic agents /
This book explains key aspects of the progress that has been made towards understanding how drugs can bind specifically to nucleic acids, and thus underpin the endeavour to make gene targeting a reality. The binding of drugs to DNA is a fast developing area of research with important applications in...
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| Corporate Authors: | |
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| Group Author: | |
| Published: |
Royal Society of Chemistry,
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| Publisher Address: | London : |
| Publication Dates: | [2018] |
| Literature type: | Book |
| Language: | English |
| Series: |
Chemical biology,
number 7 |
| Subjects: | |
| Summary: |
This book explains key aspects of the progress that has been made towards understanding how drugs can bind specifically to nucleic acids, and thus underpin the endeavour to make gene targeting a reality. The binding of drugs to DNA is a fast developing area of research with important applications in medicine, particularly the treatment of cancer. Early chapters cover methodologies to evaluate DNA-interactive agents and then the book provides examples of DNA-interactive molecules and technologies in development as therapeutic agents and treats in depth topics such as DNA-binding metal complex |
| Carrier Form: | xvii, 414 pages : illlustrations (some color), forms ; 24 cm. |
| Bibliography: | Includes bibliographical references and index. |
| ISBN: |
9781782629924 (hardcover) : 1782629920 (hardcover) 9781788012928 (PDF) 1788012925 (PDF) 9781788014281 (epub) 1788014286 (epub) |
| Index Number: | RB155 |
| CLC: | R456 |
| Call Number: | R456/D418 |
| Contents: |
DNA Recognition by Parallel Triplex Formation / Interfacial Inhibitors / Slow DNA Binding / Thermal denaturation of drug-DNA complexes / Computer Simulations of Drug-DNA Interactions: A Personal Journey / Binding of Small Molecules to Trinucleotide DNA Repeats Associated with Neurodegenerative Diseases / |