Screen LibraryRNA-based regulation in human health and disease /
Rajesh Pandey's lab focuses on Integrative Genomics of Host-Pathogen wherein RNA plays a central role towards modulating pathogenicity. RNA-Based Regulation in Human Health and Disease offers an in-depth exploration of RNA-mediated genome regulation at different hierarchies. Beginning with a mu...
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| Group Author: | |
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| Published: |
Elsevier Academic Press,
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| Publisher Address: | London : |
| Publication Dates: | [2020] |
| Literature type: | Book |
| Language: | English |
| Series: |
Translational epigenetics series ;
volume 19 |
| Subjects: | |
| Summary: |
Rajesh Pandey's lab focuses on Integrative Genomics of Host-Pathogen wherein RNA plays a central role towards modulating pathogenicity. RNA-Based Regulation in Human Health and Disease offers an in-depth exploration of RNA-mediated genome regulation at different hierarchies. Beginning with a multitude of canonical and noncanonical RNA populations, especially noncoding RNA in human physiology and evolution, further sections examine the various classes of RNAs (from small to large noncoding and extracellular RNAs), functional categories of RNA regulation (RNA-binding proteins, alternative splicing, RNA editing, antisense transcripts, and RNA G-quadruplexes), dynamic aspects of RNA regulation modulating physiological homeostasis (aging), role of RNA beyond humans, tools and technologies for RNA research (wet lab and computational), and future prospects for RNA-based diagnostics and therapeutics. One of the core strengths of the book includes spectrum of disease-specific chapters from experts in the field highlighting RNA-based regulation in metabolic and neurodegenerative disorders, cancer, inflammatory disease, viral and bacterial infections. We hope the book helps researchers, students, and clinicians appreciate the role of RNA-based regulation in genome regulation, aiding the development of useful biomarkers for prognosis, diagnosis, and novel RNA-based therapeutics. -- Page 4 of cover. |
| Carrier Form: | xix, 424 pages : illustrations (chiefly color), color charts ; 24 cm |
| Bibliography: | Includes bibliographical references and index. |
| ISBN: |
9780128171936 0128171936 |
| Index Number: | QH450 |
| CLC: |
Q756 Q522 |
| Call Number: | Q522/R627-4 |
| Contents: |
Introduction / Non-coding RNAs: ever-expanding diversity of types and functions / Subhash Chandra Lakhotia, Bibekanand Mallick and Jyoti Roy -- Functional categories of RNA regulation / The dynamic aspects of RNA regulation / RNA beyond humans / Nar Singh Chauhan, Monika, Tarun Kumar, Pinki Sharma and Khushboo Goyal -- Extracellular RNA in human health and disease / RNA and malaria pathogenesis / RNA and metabolic disorders / RNA toxicity in tandem nucleotide repeats mediated neurodegenerative disorders / Regulation by non-coding RNAs in respiratory disorders / RNA in cancer / RNA and inflammatory autoimmune diseases / RNA and bacterial infection / RNA and stress / RNA and aging / Experimental toolkit to study RNA level regulation / Industry perspective / Summary and future perspectives / |