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Integrated strategies for drug discovery using mass spectrometry

New strategies and techniques for today's fast-paced discovery processToday, the pressure is on for high-throughput approaches to accelerate the generation, identification, and optimization of molecules with desirable drug properties. As traditional methods of analysis become antiquated, new an...

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Bibliographic Details
Group Author: Lee, Mike S., 1960-
Published:
Literature type: Electronic eBook
Language: English
Subjects:
Mass spectrometry.
Drugs > Analysis.
High throughput screening (Drug development)
Drug Design.
Pharmaceutical Preparations > analysis.
Chromatography, Liquid > methods.
Pharmacokinetics.
Spectrum Analysis, Mass > methods.
MEDICAL > Drug Guides.
MEDICAL > Pharmacology.
MEDICAL > Pharmacy.
MEDICAL > Pharmacology. > Pharmacology.
Electronic books.
Online Access: http://onlinelibrary.wiley.com/book/10.1002/0471721034
Summary: New strategies and techniques for today's fast-paced discovery processToday, the pressure is on for high-throughput approaches to accelerate the generation, identification, and optimization of molecules with desirable drug properties. As traditional methods of analysis become antiquated, new analytical strategies and techniques are necessary to meet sample throughput requirements and manpower constraints.
Carrier Form: 1 online resource (xvii, 550 pages) : illustrations
Bibliography: Includes bibliographical references and index.
ISBN: 0471721026
9780471721024
047146127X
9780471461272
0471721034
9780471721031
Index Number: RS189
CLC: R917
Contents: Miniaturized formats for efficient liquid chromatography mass spectrometry-based proteomics and therapeutic development / Gary A. Valaskovic and Neil Kelleher -- Mass-spectrometry-based drug screening assays for early phases in drug discovery / Marshall M. Siegel -- ESI-FTICR as a high throughput drug discovery platform / Kristin A. Sannes-Lowery [and others] -- Mass spectrometry-based proteomic approaches for disease diagnosis and biomarker discovery / Thomas P. Conrads [and others] -- Metabonomic applications in toxicity screening and disease diagnosis / John P. Shockcor and Elaine Holmes -- The central role of mass spectrometry in natural products discovery / Jeffrey R. Gilbert [and others].
Application of mass spectrometry to compound library generation, analysis, and management / Xueheng Cheng and Jill Hochlowski -- A combinatorial process for drug discovery / David S. Wagner [and others] -- Application of technological advances in biotransformation studies / Carmen L. Fernández-Metzler, Raju Subramanian and Richard C. King -- Applications of mass spectrometry for the characterization of reactive metabolites of drugs in discovery / Jim Wang [and others] -- Advances in high throughput quantitative drug discovery bioanalysis / Bradley L. Ackermann, Michael J. Berna and Anthony T. Murphy.
New strategies for the implementation and support of bioanalysis in a drug metabolism environment / Walter A. Korfmacher -- An integrated LC-MS strategy for preclinical candidate optimization / Jonathan L. Josephs and Mark Sanders -- New approaches for method development and purification in lead optimization / Yining Zhao and David J. Semin -- High throughput metabolic and physicochemical property analysis / Edward H. Kerns and Li Di -- Organ perfusion and mass spectrometry / C. Gerald Curtis [and others] -- Sample preparation for drug discovery bioanalysis / David A. Wells -- Automation / John D. Laycock and Thomas Hartmann.

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