Screen LibraryMicrodialysis in drug development /
In vivo target site concentrations are probably the most important determinant of drug effects. Traditionally, linking drug concentrations to drug effects has been accomplished by modelling blood-derived data, mostly because a direct quantification of tissue concentrations has been beyond technical...
Saved in:
| Corporate Authors: | |
|---|---|
| Group Author: | |
| Published: |
Springer,
|
| Publisher Address: | New York, NY : |
| Publication Dates: | 2013. |
| Literature type: | eBook |
| Language: | English |
| Series: |
AAPS advances in the pharmaceutical sciences series,
4 |
| Subjects: | |
| Online Access: |
http://dx.doi.org/10.1007/978-1-4614-4815-0 |
| Summary: |
In vivo target site concentrations are probably the most important determinant of drug effects. Traditionally, linking drug concentrations to drug effects has been accomplished by modelling blood-derived data, mostly because a direct quantification of tissue concentrations has been beyond technical reach. Today, a direct measurement of target site concentrations is possible by employing microdialysis or complementary approaches such as imaging technologies. Microdialysis, initially conceived in the 1970ies, has become a standard tool in drug development. This comprehensive overview of current microdialysis technology covers general and disease-specific aspects of microdialysis by international experts in the field. It provides useful information for colleagues in academia and industry who are interested PK-PD aspects of drug development. |
| Carrier Form: | 1 online resource. |
| Bibliography: | Includes bibliographical references and index. |
| ISBN: |
9781461448150 (electronic bk.) 1461448158 (electronic bk.) |
| Index Number: | RM301 |
| CLC: | R914 |
| Contents: |
General Aspects -- Introduction to the Microdialysis Technology / Recovery and Calibration Techniques: Toward Quantitative Microdialysis / Analytical Considerations for Microdialysis Sampling / Regulatory Aspects of Microdialysis: A United States Food and Drug Administration Perspective / Specific topics -- Microdialysis in CNS PKPD Research: Unraveling Unbound Concentrations / Microdialysis in Antibiotic Research / Skin and Transdermal Drug Delivery / Translational Approaches for Predicting CNS Drug Effects Using Microdialysis / Extracellular Amyloid-[beta] Protein Dynamics in Alzheimer's Disease / Microdialysis in Pain Research / Microdialysis in Ocular Drug Development / Microdialysis in Metabolic Research / High Molecular Weight Targets and Treatments Using Microdialysis / Complementary Techniques: Positron Emission Tomography / Open Flow Microperfusion: An Alternative Method to Microdialysis? / Microdialysis in Internal Organs and Tumors / |