Screen LibraryCentrosomes in development and disease
Discovered over a century ago, the centrosome is the major microtubule organizing center of the animal cell. It is a tiny organelle of surprising structural complexity. Over the last few years our understanding of the structure and composition of centrosomes has greatly advanced, and the demonstrati...
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| Literature type: | Electronic eBook |
| Language: | English |
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| Online Access: |
http://onlinelibrary.wiley.com/book/10.1002/3527603808 |
| Summary: |
Discovered over a century ago, the centrosome is the major microtubule organizing center of the animal cell. It is a tiny organelle of surprising structural complexity. Over the last few years our understanding of the structure and composition of centrosomes has greatly advanced, and the demonstration of frequent centrosome anomalies in most common human tumors has sparked additional interest in the role of this organelle in a broader scientific community. The centrosome controls the number and distribution of microtubules--a major element of the cell cytoskeleton--and hence influences many impo. |
| Carrier Form: | 1 online resource (xxi, 431 pages) : illustrations (some color) |
| Bibliography: | Includes bibliographical references and index. |
| ISBN: |
3527309802 9783527309801 3527603808 9783527603800 3527604340 9783527604340 |
| Index Number: | QH597 |
| CLC: | Q24 |
| Contents: |
Early studies on centrioles and centrosomes -- Tubulin superfamily -- Microtubule nucleation -- The budding yeast spindle pole body: a centrosome analog -- Dissection of basal body and centriole function in the unicellular green alga chlamydomonas reinhardtii -- The centrosome in evolution -- A proteomic approach to the inventory of the human centrosome -- The role of the centrosome in cell cycle progression -- Centrosome duplication and its regulation in the higher animal cell -- A synergy of technologies: using green fluorescent protein tagging and laser microsurgery to study centrosome function and duplication in vertebrates -- Centrosome regulation in response to environmental and genotoxic stress -- The C. elegans centrosome during early embryonic development. Centrosomes in a developing organism: lessons from drosophila -- Centrosome inheritance during human fertilization and "therapeutic" cloning: reproductive and developmental diseases and disorders caused by centrosome dysfunction -- Microtubule organizing centers in polarized epithelial cells -- Centrosome anomalies in cancer: from early observations to animal models -- Radiation therapy and centrosome anomalies in pancreatic cancer -- Human papillomavirus infection and centrosome anomalies in cervical cancer -- Manipulation of centrosomes and the microtubule cytoskeleton during infection by intracellular pathogens -- Basal bodies and microtubule organization in pathogenic protozoa. |