Screen LibraryAnnual reports in medicinal chemistry. Volume sixty one, Natural products /
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| Group Author: | |
|---|---|
| Published: |
Elsevier Academic Press,
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| Publisher Address: | Amsterdam, Netherlands : |
| Publication Dates: | 2023. |
| Literature type: | Book |
| Language: | English |
| Edition: | First edition. |
| Series: |
Annual reports in medicinal chemistry,
volume 61 |
| Subjects: | |
| Carrier Form: | xi, 195 pages : illustrations (some color) ; 24 cm. |
| Bibliography: | Includes bibliographical references. |
| ISBN: | 9780443137099 |
| Index Number: | RS160 |
| CLC: | R914-54 |
| Call Number: | R914-54/A512/v.61 |
| Contents: |
Front Cover -- Natural Products -- Copyright -- Contents -- Contributors -- Preface -- Chapter One: Chemical evolution of natural product structure for drug discovery -- 1. Introduction -- 2. Pseudo-natural product design principle -- 3. Synthesis and biological evaluation of pseudo-NPs -- 3.1. Spirocyclic connection -- 3.2. Fused connection -- 3.3. Bridged connection -- 3.4. Macrocyclic connection -- 3.5. Mono-podal connection -- 4. Cheminformatic analysis -- 5. Conclusions and outlook -- Acknowledgments -- References Chapter Two: The polypharmacology of natural products in drug discovery and development -- 1. Introduction -- 2. What is polypharmacology? -- 3. Are natural products more likely to be multi-targeting as compared to synthetic drugs? -- 4. The possible mechanisms of polypharmacology in natural products -- 5. Case studies of the polypharmacology of selected natural products -- 5.1. Polypharmacology as a result of promiscuous protein binding sites -- 5.1.1. Staurosporine -- 5.2. Electrophilic natural products -- 5.2.1. Andrographolide -- 5.2.2. Celastrol Chapter Three: Pharmacology of marine drugs: Pattern-, purpose- and prudence-driven innovations -- 1. Introduction -- 2. The last 5 years (2019-2023) -- 2.1. Targeted therapies: The boom of marine natural products-based ADCs in cancer treatment -- 2.2. Optimizing natural prototypes: The approval of lurbinectedin -- 2.3. Broader than cancer: Repurposing plitidepsin to a host-mediated treatment for COVID-19 -- 3. Perspectives: Is there still room for more? -- References -- Chapter Four: Advances in natural products driven drug discovery from medicinal plants for neuropathic pain -- 1. Introduction |