Screen LibraryChaperokine activity of heat shock proteins /
Chaperokine is a term that describes the unique function of extracellular heat shock protein (eHsp) as both chaperone and cytokine. The cellular consequence of binding and signaling of eHsp is the stimulation of a potent and long lasting immune response. eHsp induces a plethora of immune responses i...
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| Group Author: | ; |
|---|---|
| Published: |
Springer,
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| Publisher Address: | Cham, Switzerland : |
| Publication Dates: | [2019] |
| Literature type: | Book |
| Language: | English |
| Series: |
Heat shock proteins,
volume 16 |
| Subjects: | |
| Summary: |
Chaperokine is a term that describes the unique function of extracellular heat shock protein (eHsp) as both chaperone and cytokine. The cellular consequence of binding and signaling of eHsp is the stimulation of a potent and long lasting immune response. eHsp induces a plethora of immune responses including the release of bioactive mediators such as cytokines, chemokines, nitric oxide, apotogenic mediators, stimulation of the innate and adaptive immune response, migration and maturation of dendritic cells (DC) and the enhancement of natural killer cell-mediated cellular cytotoxicity. This edited book provides the most comprehensive review of contemporary knowledge of the chaperokine activity of heat shock proteins (HSP) in biology and medicine. Using an integrative approach to understanding the chaperokine activity of HSP, the contributors provide an overview of novel mechanisms, signal transduction pathways and a concise understanding of how the principles of the chaperokine activity of HSP has been harnessed for therapeutic gain. Key basic and clinical research laboratories from major universities, academic medical hospitals, biotechnology and pharmaceutical laboratories around the world have contributed chapters that review present cutting-edge research activities and importantly, the future direction of chaperokine research. The book is a must read for researchers, postdoctoral fellows and graduate students in the fields of Translational Medicine, Clinical Psychology, Human Physiology, Zoology, Botany, Biotechnology, Molecular Medicine, Infectious Disease, Pathology and Pharmaceutical Sciences, as well as for researchers involved in Drug Discovery. |
| Carrier Form: | ix, 320 pages : illustrations (some color) ; 25 cm. |
| Bibliography: | Includes bibliographical references and index. |
| ISBN: |
9783030022532 3030022536 9783030022556 3030022552 |
| Index Number: | QP552 |
| CLC: | Q51 |
| Call Number: | Q51/C462 |
| Contents: |
Intro; Preface; Contents; Editors Biography; Part I: Immunological and Inflammatory Responses; Chapter 1: The Chaperokine Activity of Heat Shock Proteins; 1.1 Introduction; 1.1.1 Chaperokine-Induced Signal Transduction Pathways; 1.1.2 Biological Significance of Circulating Serum HAPA1A: Role in Host Physiology; 1.1.3 Application of Extracellular HSPA1A: HSPA12A-Based Immunotherapies; 1.1.4 Active Release Mechanism: Inflammation, Exercise, Psychological Stress, Brain and Cerebral Spinal Fluid (CSF); 1.1.5 Chaperokine-Mediated Inflammatory Responses; 1.1.6 Chaperokine Activity and Aging 3.3 Role of sHSP60 in Several Chronic Inflammatory Diseases3.3.1 Atherosclerosis; 3.3.2 Diabetes and Obesity; 3.3.3 Arthritis-Related Diseases; 3.4 Conclusions; References; Chapter 4: Heat Shock Protein 60: A Mediator of Atherosclerosis and Its Potential Therapeutic Role; 4.1 Introduction; 4.2 Heat Shock Proteins; 4.3 Heat Shock Protein 60 (HSP60); 4.4 Initiation of Immune Responses: The Chaperokine Activity of HSP60; 4.5 Early Atherosclerosis; 4.6 The "Autoimmune Concept of Atherosclerosis"; 4.7 HSP60 in Human Atherosclerosis; 4.8 HSP60-Induced Experimental Atherosclerosis 4.9 HSP60 Tolerization in Atherosclerosis4.10 HSP60 Tolerization in Other Autoimmune Diseases; 4.11 Conclusions; References; Chapter 5: Role of Heat Shock Protein 90 in Autoimmune Inflammatory Rheumatic Diseases; 5.1 Introduction; 5.2 Rheumatoid Arthritis; 5.3 Systemic Lupus Erythematosus; 5.4 Idiopathic Inflammatory Myopathies; 5.5 Systemic Sclerosis; 5.6 Other Rheumatic Diseases; 5.7 Conclusions; References; Chapter 6: Upregulation of Cytoprotective Chaperones Mediate Better Tolerance to High Altitude; 6.1 Introduction; 6.1.1 High Altitude, Hypobaric Hypoxia and Oxidtive Stress |