Screen LibraryGlycogen synthase kinase 3 (GSK-3) and its inhibitors drug discovery and development /
GSK-3 is a promising drug target that has been extensively tested, and shown great potential for treatment of diseases that have no current effective treatment? like Alzheimer?s, bipolar disorder, and cancer. GSK-3 and Its Inhibitors gathers and systematically analyzes a collection of studies and in...
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| Group Author: | ; ; |
| Published: |
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| Literature type: | Electronic eBook |
| Language: | English |
| Series: |
Wiley series in drug discovery and development
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| Subjects: | |
| Online Access: |
http://onlinelibrary.wiley.com/book/10.1002/0470052171 |
| Summary: |
GSK-3 is a promising drug target that has been extensively tested, and shown great potential for treatment of diseases that have no current effective treatment? like Alzheimer?s, bipolar disorder, and cancer. GSK-3 and Its Inhibitors gathers and systematically analyzes a collection of studies and information in a single source and tool for biochemists and cell biologists. |
| Carrier Form: | 1 online resource (xxxi, 346 pages, [8] pages of plates) : illustrations (some color). |
| Bibliography: | Includes bibliographical references and index. |
| ISBN: |
0470052171 9780470052174 0470052155 9780470052150 |
| Index Number: | QP606 |
| CLC: | Q555-1 |
| Contents: |
Glycogen synthase kinase 3: an introductory synopsis -- Glycogen synthase kinase-3[beta] (GSK-3[beta]) a key signaling enzyme: a developmental neurobiological perspective -- Role of GSK-3/Shaggy in neuronal cell biology -- The crystal structures of glycogen synthase kinase 3 -- Kinase-kinase and site-site interactions in the phosphorylation of tau by GSK-3 -- GSK-3, a key player in Alzheimer's disease -- Glycogen synthase kinase 3 : a target for novel mood disorder treatments -- GSK-3 and stem cells -- Glycogen synthase kinase 3 : role in neurodegeneration and neuroprotection. Protein kinase assays for drug discovery -- Animal models with modified expression of GSK-3 for the study of its physiology and of its implications in human pathologies -- Lithium, the seminal GSK-3 inhibitor -- Inhibition of GSK-3 as therapeutic strategy in disease : efficacy of AR-A014418 -- TDZD's: selective and ATP noncompetitive glycogen synthase kinase 3 inhibitors -- 3-amino pyrazoles as potent and selective glycogen kinase synthase (GSK-3) inhibitors -- Marine compounds as a new source for glycogen synthase kinase 3 inhibitors. |