Screen LibraryBrain metastases from primary tumors : epidemiology, biology, and therapy. Volume 1/
With an annual rate of more than 12 million global diagnoses and 7.6 million deaths, the societal and economic burden of cancer cannot be overstated. Brain metastases are the most common malignant tumors of the central nervous system, yet their incidence appears to be increasing in spite of the adva...
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| Published: |
Elsevier/Academic Press,
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| Publisher Address: | London : |
| Publication Dates: | [2014] |
| Literature type: | eBook |
| Language: | English |
| Subjects: | |
| Online Access: |
http://www.sciencedirect.com/science/book/9780128008966 |
| Summary: |
With an annual rate of more than 12 million global diagnoses and 7.6 million deaths, the societal and economic burden of cancer cannot be overstated. Brain metastases are the most common malignant tumors of the central nervous system, yet their incidence appears to be increasing in spite of the advancement of cancer therapies. While much is known about primary cancers (including primary brain tumors), less work has been done to uncover the roots of metastatic disease. This volume fills that gap, serving as the first reference to focus primarily on the link between primary cancers and brain metastases. This link is explored for the most common cancer types -- lung, breast, and melanoma. Additionally, biological background as well as therapy for CNS metastases is addressed. Age and gender related trends are also discussed, as is the use of biomarkers for early detection. |
| Carrier Form: | 1 online resource (xiii, 260 pages) : illustrations (some color) |
| Bibliography: | Includes bibliographical references and index. |
| ISBN: |
9780128010952 0128010959 9780128016893 0128016892 |
| Index Number: | RC280 |
| CLC: | R739.41 |
| Contents: | Brain metastases -- Epidemiology of central nervous system metastases -- Involvement of the CXCL12/CXCR4/CXCR7 axis in brain metastases -- Non-uniform distribution of metastatic intracranial tumors in cancer patients -- Targeting angiogenesis, enhancing radiosensitization and crossing the blood-brain barrier for brain metastases -- Second malignancies in children following treatment for neuroblastoma -- The role of chemotherapy in metastatic brain tumors -- Multiple metastases to the brain from primary cancers : whole brain radiotherapy -- Synovial sarcoma metastasized to the brain -- Multiple small brain metastases with limited focal brain edema from non-small cell lung cancer with epidermal growth factor receptor mutations -- Brain metastasis of patients with lung adenocarcinoma : epidermal growth factor receptor mutations and response to whole-brain radiation therapy -- Metastatic spread of lung cancer to brain and liver : role of CX3CR1 -- Solitary brain metastasis from non-small cell lung cancer : treatment with linac-based stereotactic radiosurgery -- Brain metastases from non-small cell lung cancer : clinical benefits of erlotinib and gefitinib -- Bispecific targeted toxin DTATEGF against metastatic NSCLC brain tumors -- Intracranial disease in patients with non-small cell lung cancer : treatment with erlotinib -- Radiation management of synchronous brain metastases from non-small cell lung cancer -- Brain metastasis after prophylactic cranial irradiation in patients with small cell lung cancer -- Brain metastasis from small-cell lung cancer with high levels of placental growth factor -- Brain metastases from lung cancer -- Lambert-Eaton myesthenic syndrome and brain metastasis from occult small cell lung carcinoma : a clinician's perspective. |