Screen LibraryCutting-edge organic synthesis and chemical biology of bioactive molecules : the shape of organic synthesis to come /
This book describes cutting-edge organic syntheses of biologically active compounds, isolation of pharmaceutically promising compounds from microorganisms, drug design, and progress on chemical biology. Synthetic strategy and tactics are summarized for super-carbon chain compounds, antitumor polycyc...
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| Group Author: | |
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| Published: |
Springer,
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| Publisher Address: | Singapore : |
| Publication Dates: | [2019] |
| Literature type: | Book |
| Language: | English |
| Subjects: | |
| Summary: |
This book describes cutting-edge organic syntheses of biologically active compounds, isolation of pharmaceutically promising compounds from microorganisms, drug design, and progress on chemical biology. Synthetic strategy and tactics are summarized for super-carbon chain compounds, antitumor polycycles, aryl C-glycoside, antimycins, duocarmycins, cannabinoids, and other compounds. Special chapters are devoted to synthesis and biochemistry of fatty acid metabolites, which play a central role in the initiation and resolution of inflammation. The book provides a quick survey of trending topics in organic synthesis and chemical tools for biological investigation, and furnishes ideas for future research in organic synthesis. In addition, the contents can easily be understood by young chemists, graduate students, and those who are looking for new research based on organic chemistry. |
| Carrier Form: | xxv, 355 pages : Illustrations (some color) ; 24 cm |
| Bibliography: | Includes bibliographical references. |
| ISBN: |
9789811362439 9811362432 |
| Index Number: | QD262 |
| CLC: | O621.3 |
| Call Number: | O621.3/C991 |
| Contents: | 1. Microbial Fraction Library: A Screening Source for Drug Discovery / Toshihiko Nogawa, Julius Adam V. Lopez, and Hiroyuki Osada -- 2. Efficient Total Synthesis of Ōmura Natural Products / Toshiaki Sunazuka, Tomoyasu Hirose, and Satoshi Ōmura -- 3. Enantioselective Total Synthesis of the Antitumor Polycyclic Natural Products, FR182877 and Taxol / Masahisa Nakada -- 4. Synthetic Approaches on the Pluramycin-class Antibiotics / Yoshio Ando, Kei Kitamura, Takashi Matsumoto, and Keisuke Suzuki -- 5. Recent Progress Toward the Total Synthesis of Duocarmaycins A and SA, Yatakemaycin, and PDE-I and -II / Juri Sakata and Hidetoshi Tokuyama -- 6. Structure-Activity Relationship Studies of Maitotoxin Based on Chemical Synthesis / Tohru Oishi -- 7. Substitution of Allylic Picolinates with Various Copper Reagents and Synthetic Applications / Yuichi Kobayashi and Miwa Shimoda -- 8. Total Synthesis of Ingenol / Tyler F. Higgins and Jeffrey D. Winkler -- 9. Strategies for Synthesis of Anti-inflammatory Metabolites of Unsaturated Fatty Acids / Yuichi Kobayashi and Masao Morita -- 10. Biosynthesis, biological functions, and receptors of leukotriene B4 and 12(S)-hydroxyheptadecatrienoic acid / Toshiaki Okuno and Takehiko Yokomizo -- 11. Synthesis of classical/non-classical hybrid cannabinoids and related compounds / Thanh C. Ho and Marcus A. Tius -- 12. Exploring bioactive marine natural products and identification of their molecular targets / Masayoshi Arai -- 13. Target protein chemical modification / Hiroyuki Nakamura -- 14. Target Identification of Bioactive Compounds by Photoaffinity Labeling Using Diazido Probes / Suguru Yoshida and Takamitsu Hosoya. |