Screen LibraryCancer metastasis：biologic basis and therapeutics
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| Group Author: | ; ; |
|---|---|
| Published: |
Cambridge University Press,
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| Publisher Address: | New York, N.Y. |
| Publication Dates: | 2011. |
| Literature type: | Book |
| Language: | English |
| Subjects: | |
| Carrier Form: | xvii, 642 p: ill. (some col.) ; 29 cm. |
| ISBN: |
9780521887212 (hbk.) 0521887216 (hardback) |
| Index Number: | R73 |
| CLC: | R73-37 |
| Call Number: | R73-37/C215-2 |
| Contents: |
Includes bibliographical references and index. Basic research -- Models and tools for metastasis studies -- Animal models of cancer metastasis -- Drosophilia and zebrafish: genetic models for cancer metastasis -- Computational models -- Intravital microscopy to visualize invasion and metastasis -- Genes -- Metastasis-promoting genes -- Role of metastasis suppressor genes in metasis -- Stromal-derived factors that dictate organ-specific metastasis -- Metastasis genes: epigenetics -- Germline variation and other host determinants of metastatic potential -- Influence of aging and cellular senescence on metasasis -- Various properties of can "Metastasis is responsible for a large burden of morbidity and mortality among cancer patients, and currently few therapies specifically target metastatic disease. Further scientific dissection of the underlying pathways is required to pave the way for new therapeutic targets. This groundbreaking new text comprehensively covers the processes underlying cancer metastasis and the clinical treatment of metastatic disease. Whereas previous volumes have been compendia of laboratory research articles, the internationally renowned authors of this volume have summarized the state-of-the-art research |