Screen LibraryUltrastructure of mast cells and basophils
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| Main Authors: | |
|---|---|
| Published: |
Karger,
|
| Publisher Address: | Basel New York |
| Publication Dates: | 2005. |
| Literature type: | Book |
| Language: | English |
| Series: |
Chemical immunology and allergy, ; v. 85 |
| Subjects: | |
| Carrier Form: | xi, 351 p.: ill. ; 25 cm. |
| ISBN: |
3805578644 (hd.bd. : alk. paper) 9783805578646 (hd.bd. : alk. paper) |
| Index Number: | R322 |
| CLC: |
R322.2 R331.1 |
| Call Number: | R331.1/D988 |
| Contents: |
Includes bibliographical references (p. 319-344) and index. Ultrastructure analysis is necessary and sufficient for identification of basophils and mast cells -- Cyclooxygenase, a key enzyme family for production of prostaglandins, is present in human mast cell lipid bodies -- Subcellular localization of the cytokines, basic fibroblast growth factor and tumor necrosis factor-alpha in mast cells -- Immunogold ultrastructural techniques identify subcellular sites of chymase, charcot-leyden crystal protein, and histamine in basophils and mast cells -- Ultrastructural enzyme-affinity-gold and inhibitor-gold techniques identify subcellular sites of histamine and heparin in basophils and mast cells -- Piecemeal degranulation of basophils and mast cells is effected by vesicular transport of stored secretory granule contents -- Mast cell-derived mediators of enhanced microvascular permeability, vascular permeability factor/ vascular endothelial growth factor, histamine, and serotonin, cause leakage of macromolecules through a new endothelial cell permeability organelle, the vesiculo-vacuolar organelle -- Degranulation and recovery from degranulation of basophils and mast cells -- Mast cell secretory granules and lipid bodies contain the necessary machinery important for the in situ synthesis of proteins. |