Screen LibraryAnalysis and Purification Methods in Combinatorial Chemistry, Volume 163
Quality measurement, control, and improvement incombinatorial chemistryCombinatorial chemistry has developed rapidly in the past decade, with greatadvances made by scientists working on analysis and purification of a largenumber of compounds and the analysis of polymer-bound compounds. However, form...
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| Literature type: | Electronic eBook |
| Language: | English |
| Edition: | 1st ed. |
| Series: |
Chemical analysis: a series of monographs on analytical chemistry and its applications
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| Online Access: |
http://onlinelibrary.wiley.com/book/10.1002/0471531979 |
| Summary: |
Quality measurement, control, and improvement incombinatorial chemistryCombinatorial chemistry has developed rapidly in the past decade, with greatadvances made by scientists working on analysis and purification of a largenumber of compounds and the analysis of polymer-bound compounds. However, formidable challenges lie ahead of today's researcher. For example, high-throughput analysis and purification technologies must be furtherdeveloped to ensure combinatorial libraries are "purifiable," and "drugable." To this end, Analysis and Purification Methods inCombinatorial Chemistry describes various analytical techniques and systems forthe development, validation, quality control, purification, and physicochemicaltesting of combinatorial libraries. A new volume in Wiley's Chemical Analysisseries, this text has four parts covering: *Various approaches to monitoring reactions on solid support and optimizing reactions for library synthesis *High-throughput analytical methods used to analyze the quality of libraries *High-throughput purification techniques *Analytical methods applied in post-synthesis and post-purification stagesDrawing from the contributions of respected experts incombinatorial chemistry, this comprehensive book provides coverage ofapplications of Nuclear Magnetic Resonance (NMR), liquid chromatography/massspectrometry (LC/MS), Fourier Transform Infrared (FTIR), micellarelectrokinetic chromatography (MEKC) technologies, as well as other analyticaltechniques. This eminently useful volume is an essential addition to thelibrary of students and researchers studying or working in analyticalchemistry, combinatorial chemistry, medicinal chemistry, organic chemistry, biotechnology, biochemistry, or biophysics. |
| Carrier Form: | xxx, 466 pages. |
| ISBN: |
0471531979 9780471531975 |
| Index Number: | RS419 |
| CLC: | O65 |
| Contents: | Frontmatter -- Analysis for Feasibility and Optimization of Library Synthesis. Quantitative Analysis in Organic Synthesis with NMR Spectroscopy / Laura H Lucas, Cynthia K Larive -- F Gel-Phase NMR Spectroscopy for Reaction Monitoring and Quantification of Resin Loading / Joseph M Salvino -- The Application of Single-Bead FTIR and Color Test for Reaction Monitoring and Building Block Validation in Combinatorial Library Synthesis / Jason J Cournoyer, Clinton A Krueger, Janice V Wade, Bing Yan -- HR-MAS NMR Analysis of Compounds Attached to Polymer Supports / Meritxell Guin̤, Yolanda R de Miguel -- Multivariate Tools for Real-Time Monitoring and Optimization of Combinatorial Materials and Process Conditions / Radislav A Potyrailo, Ronald J Wroczynski, John P Lemmon, William P Flanagan, Oltea P Siclovan -- Mass Spectrometry and Soluble Polymeric Support / Christine Enjalbal, Frederic Lamaty, Jean Martinez, Jean-Louis Aubagnac -- High-Throughput Analysis for Library Quality Control. High-Throughput NMR Techniques for Combinatorial Chemical Library Analysis / Ting Hou, Daniel Raftery -- Micellar Electrokinetic Chromatography as a Tool for Combinatorial Chemistry Analysis: Theory and Applications / Peter J Simms -- Characterization of Split-Pool Encoded Combinatorial Libraries / Jing Jim Zhang, William L Fitch -- High-Throughput Purification to Improve Library Quality. Strategies and Methods for Purifying Organic Compounds and Combinatorial Libraries / Jiang Zhao, Lu Zhang, Bing Yan -- High-Throughput Purification: Triage and Optimization / Jill Hochlowski -- Parallel HPLC in High-Throughput Analysis and Purification / Ralf God, Holger Gumm -- Analysis for Compound Stability and Drugability. Organic Compound Stability in Large, Diverse Pharmaceutical Screening Collections / Kenneth L Morand, Xueheng Cheng -- Quartz Crystal Microbalance in Biomolecular Recognition / Ming-Chung Tseng, I-Nan Chang, Yen-Ho Chu -- High-Throughput Physicochemical Profiling: Potential and Limitations / Bernard Faller -- Solubility in the Design of Combinatorial Libraries / Christopher Lipinski -- High-Throughput Determination of Log Values by LC/MS Method / Jenny D Villena, Ken Wlasichuk, Donald E Schmidt, James J Bao -- Index -- Chemical Analysis. |