Screen LibraryWhat's wrong with my mouse? behavioral phenotyping of transgenic and knockout mice /
This new edition of Whats Wrong With My Mouse? continues to provide the most thorough overview of mutant mouse technology and a readable introduction to the field of behavioural neuroscience as applied to behavioural phenotyping of transgenic and knockout mice.
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| Literature type: | Electronic eBook |
| Language: | English |
| Edition: | 2nd ed. |
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| Online Access: |
http://onlinelibrary.wiley.com/book/10.1002/0470119055 |
| Summary: |
This new edition of Whats Wrong With My Mouse? continues to provide the most thorough overview of mutant mouse technology and a readable introduction to the field of behavioural neuroscience as applied to behavioural phenotyping of transgenic and knockout mice. |
| Carrier Form: | 1 online resource (xvi, 523 pages) : illustrations |
| Bibliography: | Includes bibliographical references (pages 383-501) and index. |
| ISBN: |
9780470119051 0470119055 9780470119044 0470119047 |
| Index Number: | QP356 |
| CLC: | R741 |
| Contents: | Designer mice : scope and sourcebooks -- Of unicorns and chimeras : how to generate a transgenic or knockout mouse for behavioral phenotyping -- General health : give your mouse a physical -- Motor functions : open field, holeboard, rotarod, balance, grip, circadian activity, circling, stereotypy, ataxic gait, seizures -- Sensory abilities : olfaction, vision, hearing, taste, touch, nociception -- Learning and memory : Morris swim task, spatial mazes, cued and contextual conditioning, conditioned taste aversion, conditioned eyeblink, olfactory discrimination, social recognition, passive avoidance, schedule controlled operant tasks, motor learning, attention -- Feeding and drinking : daily consumption, restricted access, choice tests, microstructural analysis -- Reproductive behaviors : sexual and parental behaviors -- Social behaviors : social interaction, nesting, grooming, juvenile play, aggression -- Emotional behaviors : animal models of psychiatric disorders : mouse models of fear, anxiety, depression, schizophrenia -- Reward : self-administration of addictive drugs, conditioned place preference -- Neurodevelopment and neurodegeneration : assaying behaviours in infant, juvenile, and aged mice -- Putting it all together : choice of tests, order of testing, number of mice, equipment, housing and testing environment -- The next generation : conditional and inducible mutations, viral vector gene delivery, RNA silencing, quantitative trait loci analysis, DNA microarrays, chemical mutagenesis, gene therapy, ethical issues. |