Screen LibraryProtein-protein and domain-domain interactions /
This book illustrates the importance and significance of the molecular (physical and chemical) and evolutionary (gene fusion) principles of protein-protein and domain-domain interactions towards the understanding of cell division, disease mechanism and target definition in drug discovery. It describ...
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| Main Authors: | |
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| Group Author: | |
| Published: |
Springer,
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| Publisher Address: | Singapore : |
| Publication Dates: | [2018] |
| Literature type: | Book |
| Language: | English |
| Subjects: | |
| Summary: |
This book illustrates the importance and significance of the molecular (physical and chemical) and evolutionary (gene fusion) principles of protein-protein and domain-domain interactions towards the understanding of cell division, disease mechanism and target definition in drug discovery. It describes the complex issues associated with this phenomenon using cutting edge advancement in Bioinformatics and Bioinformation Discovery. The chapters provide current information pertaining to the types of protein-protein complexes (homodimers, heterodimers, multimer complexes) in context with various specific and sensitive biological functions. The significance of such complex formation in human biology in the light of molecular evolution is also highlighted using several examples. The chapters also describe recent advancements on the molecular principles of protein-protein interaction with reference to evolution towards target identification in drug discovery. Finally, the book also elucidates a comprehensive yet a representative description of a large number of challenges associated with the molecular interaction of proteins. |
| Carrier Form: | xix, 207 pages : illustrations (some color) ; 24 cm |
| Bibliography: | Includes bibliographical references. |
| ISBN: |
9789811073465 9811073465 |
| Index Number: | QP551 |
| CLC: | Q51 |
| Call Number: | Q51/K164 |
| Contents: | 1. Introduction -- 2. Protein-protein binding -- 3. Low-resolution protein complexes -- 4. Heterodimer protein complexes -- 5. Homo multimer protein complexes -- 6. Hetero multimer protein complexes -- 7. Hot spots at the protein-protein interface -- 8. Principles of protein-protein interaction -- 9. Databases for protein-protein interaction -- 10. Homodimer protein folding and binding -- 11. Protein subunit-subunit to domain-domain interactions -- 12. Domain-domain interactions -- 13. Protein-protein interaction tools -- 14. Protein-protein docking: Methods and tools -- 15. HLA-peptide interaction to short peptide vaccine design -- 16. Protein-protein interfaces and diseases -- 17. Patented protein structural complexes in discovery platform -- 18. Proteome-scale analysis of protein complexes -- 19. Conclusions and challenges -- Useful formula. |