Screen LibraryBrain metastases from primary tumors. Volume 3, Epidemiology, biology, and therapy of melanoma and other cancers /
Brain Metastases from Primary Tumors Volume Three: Epidemiology, Biology, and Therapy of Melanoma and Other Cancers provides a comprehensive overview of the metastasis of cancer, the main cause of approximately 90% of cancer associated deaths, yet the mechanisms governing this clinically important p...
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| Published: |
Academic Press is an imprint of Elsevier,
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| Publisher Address: | Amsterdam : |
| Publication Dates: |
[2016] ©2016 |
| Literature type: | eBook |
| Language: | English |
| Subjects: | |
| Online Access: |
http://www.sciencedirect.com/science/book/9780128035085 |
| Summary: |
Brain Metastases from Primary Tumors Volume Three: Epidemiology, Biology, and Therapy of Melanoma and Other Cancers provides a comprehensive overview of the metastasis of cancer, the main cause of approximately 90% of cancer associated deaths, yet the mechanisms governing this clinically important process remain poorly understood. Melanoma is the third most common diagnosis among patients with brain metastases, after lung and breast cancer. Approximately 75% of patients with metastatic melanoma develop brain metastases during the course of their disease. Although tumorigenesis of melanoma remains poorly understood, recent advances in gene expression profiling have revealed molecular mechanisms of this deadly disease. In addition, high-throughput gene expression has many advantages over techniques in cancer transcriptomic studies and has led to the discovery of numerous diagnostic, prognostic, and therapeutic targets, which are also detailed in this book. The book discusses the link between primary tumors and brain metastasis of melanoma, including molecular mechanisms, treatment options, prognosis, and general applications. Comprehensive chapters discuss systemic therapy, integrin inhibitors, stereotaxic radiosurgery, and more, making this book a great resource for neurooncologists, neurosurgeons, neurologists, and cancer researchers. |
| Carrier Form: | 1 online resource (384 pages) |
| Bibliography: | Includes bibliographical references and index. |
| ISBN: |
9780128035597 0128035595 |
| Index Number: | RC280 |
| CLC: | R739.41 |
| Contents: |
Front Cover; Brain Metastases from Primary Tumors; Copyright Page; Contents; Preface; Contributors; Volume 1-Contributions; Volume 2-Contributions; I. MOLECULAR MECHANISMS; 1 Introduction; Melanoma; Treatment; Breast Cancer; Treatment; Esophageal Cancer; Treatment; References; 2 The Management and Biology of Metastatic Cancers to the Brain; Introduction; BBB Structure; Molecular Changes in the BBB with Metastatic Lesions; The Role of P-Glycoprotein; Local and Supportive Treatments; Systemic and Targeted Therapies; General Principles; Breast Cancer; Lung Adenocarcinoma; Melanoma; Conclusion AcknowledgmentsReferences; 3 Melanoma Metastases Are Underrepresented in Cerebellum Compared with Metastases from Colorectal Cancers; Introduction; Epidemiology; The Pathogenesis of Brain Metastasis; Histology of Primary Cancer; Cerebellar Metastases; The Oslo University Hospital Experience; Clinical Setting; Statistics; Origin of Primary Tumor; Incidence of Cerebellar versus Supratentorial Brain Metastases; Incidence of Cerebellar Malignant Melanomas Metastases; Incidence of Cerebellar Colorectal Cancer Metastases; Discussion; Malignant Melanomas; Coloectal Cancers; Conclusions; References Surgery for Melanoma Brain MetastasesHistorical Role of Surgery for Melanoma Brain Metastases; Current Indications for Surgical Management of Melanoma Brain Metastases; Technical Aspects of Surgical Resection of Melanoma Brain Metastases; Complications Following Surgical Resection of Melanoma Brain Metastases; Radiation Therapy for Melanoma Brain Metastases; Single Metastasis or Oligometastatic Disease: The Role of Stereotactic Radiosurgery; Single Metastases or Oligometastatic Disease: The Role of Whole Brain Radiation Therapy in Melanoma After Local Treatment o ... Minimizing the Risk of Neurological Deficit Following Whole Brain Radiation Therapy: Hippocampal SparingMultiple Metastases: The Role of Whole Brain Radiation Therapy; The Current Role of Radiation Therapy in Melanoma Brain Metastases; Systemic Therapies for Melanoma Brain Metastases; Chemotherapy; Small Molecule Targeted Therapies: BRAF, MEK, and KIT Inhibitors; BRAF Inhibitors: Dabrafenib and Vemurafenib; Immunotherapy; Interleukin-2; Check Point Inhibitors: CTLA-4 Inhibition and PD-1/PDL-1 Axis Inhibition; Suggested Approach to Management; Conclusions; References |