Screen LibraryAnimal cell biotechnology : in biologics production /
This book introduces the fundamental principles and practical application of techniques used in the scalable production of proteins and virus-based gene-therapeutic products with animal cell cultures. The book reviews a broad spectrum of subjects relevant to biologics production, including the creat...
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| Corporate Authors: | |
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| Group Author: | ; |
| Published: |
De Gruyter,
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| Publisher Address: | Berlin/Boston : |
| Publication Dates: | [2014] |
| Literature type: | eBook |
| Language: | English |
| Subjects: | |
| Online Access: |
http://dx.doi.org/10.1515/9783110278965 http://www.degruyter.com/doc/cover/9783110278965.jpg |
| Summary: |
This book introduces the fundamental principles and practical application of techniques used in the scalable production of proteins and virus-based gene-therapeutic products with animal cell cultures. The book reviews a broad spectrum of subjects relevant to biologics production, including the creation of cell lines, a survey of functional genomics for cell lines and processes, and advances in upstream and downstream process development. It is an essential reference for all those working in the biotechnology field both from an academic and industrial standpoint. |
| Carrier Form: |
1 online resource(xv,702pages) : illustrations Also available in print edition. |
| Bibliography: | 172 farb. Abb., 50 schw.-w. Tab. |
| ISBN: | 9783110278965（electronic bk.） |
| Index Number: | TP248 |
| CLC: | Q813 |
| Contents: |
Frontmatter -- Preface -- Contents -- List of Contributing Authors -- 1.1 Industrial Use and Perspectives of Animal Cell Culture / 2.1 Generation of Cell Lines and Biotechnological Applications / 2.2 CHO History, CHO Evolution and CHO Genomics an Unsolvable Enigma? / 2.3 Cell Lines for Vaccine Production / 2.4 Cell Line Monitoring: Molecular Cytogenetic Characterization / 2.5 Quality Control Essentials in Human Cell Culture: Cell Line Cross-contamination and Microbiological Infections / 3.1 Cell Line Evolution and Engineering / 3.2 Chromosome Rearrangements and Gene Amplification / 3.3 Synthetic Biology Principles for Engineering Mammalian Designer Cells / 3.4 Rational Approaches for Transgene Expression: Targeted Integration and Episomal Maintenance / 3.5 Manipulation of Cell Growth, Metabolism and Product Quality Attributes / 4.1 Control of Biotheraputics Glycosylation / 4.2 Manufacturing of Complex Biotherapeutic Protein Products: Medical Need and Rational for Monoclonal Antibody Mixtures, Multispecific Formats, and Fc-fusion Proteins / 5.1 Physiology and Metabolism of Animal Cells for Production / 5.2 Functional -Omics for Cell Lines and Processes: The -Omics Technologies on the Example of CHO Cells / |