Screen LibraryHigh content screening : a powerful approach to systems cell biology and phenotypic drug discovery /
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| Group Author: | ; |
|---|---|
| Published: |
Humana Press,
|
| Publisher Address: | New York, NY : |
| Publication Dates: | [2018] |
| Literature type: | Book |
| Language: | English |
| Edition: | Second edition. |
| Series: |
Methods in molecular biology,
1683 Springer protocols |
| Subjects: | |
| Carrier Form: | xiii, 397 pages : illustrations (chiefly color) ; 27 cm. |
| Bibliography: | Includes bibliographical references and index. |
| ISBN: |
9781493973552 149397355X |
| Index Number: | QH506 |
| CLC: |
R914.2 R965.1 |
| Call Number: | R965.1/H638/2nd ed. |
| Contents: | Applications and Caveats on the Utilization of DNA-specific Probes in Cell-based Assays -- General Staining and Segmentation Procedures for High Content Imaging and Analysis -- Tools to Measure Cell Health and Cytotoxicity Using High Content Imaging and Analysis -- Cell-based High Content Analysis of Cell Proliferation and Apoptosis -- Tools to Measure Autophagy using High Content Imaging and Analysis -- Guidelines for Microplate Selection in High Content Imaging -- Quality Control for High-Throughput Imaging Experiments using Machine Learning in CellProfiler -- High Content Screening Approaches That Minimize Confounding Factors in RNAi, CRISPR and Small Molecule Screening -- Strategies and solutions to Maintain and Retain Data from High Content Imaging, Analysis, and Screening Assays -- Live-Cell High Content Screening in Drug Development -- Challenges and Opportunities in Enabling High-Throughput, Miniaturized High-Content Screening -- Translocation Biosensors -- Versatile Tools to Probe Protein Functions In Living Cells -- High Content Positional Biosensor Assay to Screen for Compounds that Prevent or Disrupt Androgen Receptor and Transcription Intermediary Factor 2 Protein-Protein Interactions -- High Content Imaging Assays for IL-6-induced STAT3 Pathway Activation in Head and Neck Cancer Cell Lines -- Single Cell and Population Level Analysis of HCA Data -- Utilization of Multidimensional Data in the Analysis of Ultra High Throughput High Content Phenotypic Screens -- High Content Screening of Mammalian Primary Cortical Neurons -- Human Derived Neurons and Neural Progenitor Cells in High Content Imaging Applications -- Determination of Hepatotoxicity in iPSC-Derived Hepatocytes by Multiplexed High-Content Assays -- The Generation of Three-Dimensional Head and Neck Cancer Models for Drug Discovery in 384-well Ultra-Low Attachment Microplates -- An Endothelial Cell/Mesenchymal Stem Cell Co-Culture Cord Formation Assay to Model Vascular Biology In Vitro -- High-throughput Automated Chemical Screens in Zebrafish. |