Screen LibraryDrug membrane interactions analysis, drug distribution, modeling /
Barrier, reservoir, target site - those are but some of the possible functions of biological lipid membranes in the complex interplay of drugs with the organism. A detailed knowledge of lipid membranes and of the various modes of drug-membrane interaction is therefore the prerequisite for a better u...
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| Main Authors: | |
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| Published: |
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| Literature type: | Electronic eBook |
| Language: | English |
| Series: |
Methods and principles in medical chemistry ;
15 |
| Subjects: | |
| Online Access: |
http://onlinelibrary.wiley.com/book/10.1002/3527600639 |
| Summary: |
Barrier, reservoir, target site - those are but some of the possible functions of biological lipid membranes in the complex interplay of drugs with the organism. A detailed knowledge of lipid membranes and of the various modes of drug-membrane interaction is therefore the prerequisite for a better understanding of drug action. Many of today's pharmaceuticals are amphiphilic or catamphiphilic, enabling them to interact with biological membranes. Crucial membrane properties are surveyed and techniques to elucidate drug-membrane interactions presented, including computer-aided predictions. Effect. |
| Carrier Form: | 1 online resource (approximately 354 pages) : illustrations. |
| Bibliography: | Includes bibliographical references and index. |
| ISBN: |
9783527616497 3527616497 3527600639 9783527600632 |
| Index Number: | RM301 |
| CLC: | R969.1 |
| Contents: | Drug-Membrane Interactions; Contents; Preface; Foreword; Introduction; 1 Function, Composition, and Organization of Membranes; 2 Octanol-Water Partitioning versus Partitioning into Membranes; 3 Analytical Tools for the Analysis and Quantification of Drug-Membrane Interactions; 4 Drug-Membrane Interaction and Pharmacokinetics of Drugs; 5 Drug-Membrane Interactions and Pharmacodynamics; 6 Computer Simulation of Phospholipids and Drug-Phospholipid Interactions; Index. |