Clinical pharmacokinetics and pharmacodynamics:concepts and applications

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Bibliographic Details
Main Authors: Rowland Malcolm.
Group Author: Tozer Thomas N.
Published: Wolters Kluwer Health/Lippincott William & Wilkins,
Publisher Address: Philadelphia
Publication Dates: c2011.
Literature type: Book
Language: English
Edition: 4th ed.
Subjects:
Item Description: Clinical pharmacokinetics.
Carrier Form: xxii, 839 p.: ill. ; 26 cm.
ISBN: 9780781750097
0781750091
Index Number: R969
CLC: R969.1
Call Number: R969.1/R883/4th.ed.
Contents: Rev. ed. of: Clinical pharmacokinetics. 1995.
Includes index.
Therapeutic relevance -- Fundamental concepts and terminology -- Kinetics following an intravenous bolus dose -- Membranes and distribution -- Elimination -- Kinetics following an extravascular dose -- Absorption -- Response following a single dose -- Therapeutic window -- Constant-rate input -- Multiple-dose regimens -- Variability -- Genetics -- Age, weight, and gender -- Disease -- Nonlinearities -- Drug interactions -- Initiating and managing therapy -- Distribution kinetics -- Metabolites and drug response -- Protein drugs -- Prediction and refinement of human kinetics from in vitro, preclinical, and early clinical data.