Screen LibraryFrontiers in autism research : new horizons for diagnosis and treatment /
This unique book focuses on the emerging and expanding areas of research on autism spectrum disorders (ASD). These areas include investigations of genome-wide genetics and epigenetic contributions, metabolic and immune dysfunction, gene-environment interactions, as well as the role of alternative sp...
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| Published: |
World Scientific Pub. Co.,
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| Publisher Address: | Singapore ; Hackensack, N.J. : |
| Publication Dates: | 2014. |
| Literature type: | eBook |
| Language: | English |
| Subjects: | |
| Online Access: |
http://www.worldscientific.com/worldscibooks/10.1142/9146#t=toc |
| Summary: |
This unique book focuses on the emerging and expanding areas of research on autism spectrum disorders (ASD). These areas include investigations of genome-wide genetics and epigenetic contributions, metabolic and immune dysfunction, gene-environment interactions, as well as the role of alternative splicing, RNA editing, and noncoding RNAs in gene regulation. Advances in targeted or personalized therapies and alternative interventions, such as music and art therapy, are also presented. In addition, current research on issues involving adults with ASD, a population that has been sorely neglected in the field of autism, is discussed. Within each chapter, experts will review the current status of autism research in his/her field as well as provide a look at the direction where the field will (or should) be headed over the next five years and discuss the translational (practical) outcomes that are anticipated through this research. Some chapters are devoted to the development of molecular or genetic diagnostics for ASD, and novel therapeutic options that are emerging based upon new biological findings on specific genes, pathways, and metabolic functions disrupted in ASD. These unique features are designed to provide "food for thought" for future studies on autism. Hence, this book will be of value not only to established investigators and students conducting research on autism, but also to the general population especially families of individuals affected by ASDs. |
| Carrier Form: | 1 online resource (xxv,697pages) : illustrations (some color) |
| Bibliography: | Includes bibliographical references and index. |
| ISBN: | 9789814602167 |
| Index Number: | RC553 |
| CLC: | R749.405 |
| Contents: | ch. 1. Phenotype definition: A cornerstone of autism research, diagnosis and therapy / Valerie W. Hu -- ch. 2. From molecular pathways to ASD therapy: Insights from syndromic forms of autism / Laura Nicholls, Radhika Ramadas and Irina Voineagu -- ch. 3. Language impairment in autism spectrum disorders / Natalia Rakhlin and Elena L. Grigorenko -- ch. 4. Whole genome sequencing in autism: Clinical translation / Ryan K.C. Yuen and Stephen W. Scherer -- ch. 5. The impact of integrative unconventional data analysis approaches on advancing autism genetics research / Zohreh Talebizadeh and Ayten Shah -- ch. 6. Construction of a genetic classifier for ASD using gene pathway analysis / Gursharan Chana ... [et al.] -- ch. 7. Genome-wide expression studies of blood and lymphoblastoid cell lines in autism spectrum disorders / Boryana Stamova and Frank R. Sharp -- ch. 8. Searching in the "Dark": Non-coding RNA as a new avenue of autism research / Tewarit Sarachana and Valerie W. Hu -- ch. 9. Targeting noncoding RNA for treatment of autism spectrum disorders / Jessica DeWitt and Daniel B. Campbell -- ch. 10. A-to-I RNA editing in autism spectrum disorder / Alal Eran, Isaac S. Kohane and Louis M. Kunkel -- ch. 11. Translational control of autism and fragile-X syndrome / Christos G. Gkogkas ... [et al.] -- ch. 12. Epigenetics in autism / Matthew Ginsberg and Marvin Natowicz -- ch. 13. The epigenetics of autism - Running beyond the bases / Simon G. Gregory -- ch. 14. Genes and environment in autism spectrum disorders: An integrated perspective / Kelly M. Bakulski, Alison B. Singer and M. Daniele Fallin -- ch. 15. The potential brain drain from environmental exposures on the methylome and genome across generations / Janine M. LaSalle and Keith W. Dunaway -- ch. 16. The potential brain drain from environmental exposures on the methylome and genome across generations / Janine M. LaSalle and Keith W. Dunaway -- ch. 17. Maternal autoantibodies in autism spectrum disorder / Karen L. Jones and Judy Van de Water -- ch. 18. Why is autism more common in males? / Simon Baron-Cohen ... [et al.] -- ch. 19. Future directions in psychopharmacology of autism spectrum disorder / Deepali Mankad and Evdokia Anagnostou -- ch. 20. Medical co-morbidities in autism: Clues to underlying biological mechanisms and/or diagnostic subtypes? / Margaret L. Bauman -- ch. 21. Translational implications of a whole-body approach to brain health in autism: How transduction between metabolism and electrophysiology points to mechanisms for neuroplasticity / Martha R. Herbert -- ch. 22. Achieving optimal outcomes in autism: Treating potentially reversible conditions associated with autism spectrum disorder / Richard E. Frye and Daniel A. Rossignol -- ch. 23. Transcranial magnetic stimulation: Application in autism treatment / Manuel F. Casanova and Estate M. Sokhadze -- ch. 24. Music therapy: Personalized interventions for individuals with autism spectrum disorder / Petra Kern -- ch. 25. The contributions of art therapy in treatment, assessment, and research with people who have autism spectrum disorders / Donna Betts, Rebecca Harmer and Gabriela Schmulevich -- ch. 26. Shifting paradigms: An examination of our understanding of adult autism / Rhonda J. Greenhaw. |