Screen LibraryNovel optical endoscopes for early cancer diagnosis and therapy /
This thesis describes the design, development, characterisation and clinical translation of three novel devices for optical endoscopic imaging. Over the past decade, rapid innovation in optics and photonics has led to the availability of low-cost and high-performance optical technologies that can be...
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| Main Authors: | |
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| Published: |
Springer,
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| Publisher Address: | Cham : |
| Publication Dates: | [2019] |
| Literature type: | Book |
| Language: | English |
| Series: |
Springer theses,
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| Subjects: | |
| Summary: |
This thesis describes the design, development, characterisation and clinical translation of three novel devices for optical endoscopic imaging. Over the past decade, rapid innovation in optics and photonics has led to the availability of low-cost and high-performance optical technologies that can be exploited for biomedical applications, but relatively few have been translated into clinic. The work presented outlines for the first time, a comprehensive analysis of the common barriers and unique challenges associated with the translation of optical imaging techniques. To assist developers str |
| Item Description: | "Doctoral thesis accepted by the University of Cambridge, Cambridge, UK." |
| Carrier Form: | xxi, 142 pages : illustrations (some color) ; 25 cm. |
| Bibliography: | Includes bibliographical references. |
| ISBN: |
9783030214807 303021480X 9783030214821 3030214826 9783030214838 3030214834 |
| Index Number: | RC78 |
| CLC: |
R730.4 R443 |
| Call Number: | R443/W326 |
| Contents: |
Intro; Supervisor's Foreword; Abstract; List of Publications; Publications; Conference Proceedings; Acknowledgements; Contents; Abbreviations; 1 Translation of Optical Imaging Techniques; 1.1 The Potential of Optical Imaging in Oncology; 1.2 Challenges of Clinical Translation of Optical Imaging Techniques; 1.3 The Optical Imaging Biomarker Roadmap; 1.3.1 Barriers to Translation of Optical Imaging Techniques; 1.3.2 Translational Characteristics of Optical Imaging Techniques; 1.4 Outlook; References; 2 Flexible Endoscopy: Early Detection of Dysplasia in Barrett's Oesophagus 2.1 Barrett's Oesophagus2.2 Improving the Standard of Care; 2.2.1 Categories of Advanced Optical Endoscopic Techniques; 2.2.2 Advanced Optical Endoscopic Techniques in Clinical Practice for Barrett's Surveillance; 2.2.3 Emerging Optical Endoscopic Techniques for Barrett's Surveillance; 2.3 Summary; References; 3 Flexible Endoscopy: Device Architecture; 3.1 Flexible Endoscopic Device Architectures; 3.2 The PolyScope Accessory Channel Endoscope; 3.3 Comb Correction Methods; 3.3.1 Experimental System; 3.3.2 Simulated Images; 3.3.3 Monochrome Image Comb Correction 3.3.4 Multispectral Image Comb Correction3.3.5 Performance Metrics; 3.3.6 Overall Performance; 3.4 Comb Correction Results; 3.4.1 Performance of Simulated Monochrome Image Corrections; 3.4.2 Performance of Experimentally Captured Monochrome Image Corrections; 3.4.3 Performance of Captured Multispectral Image Corrections; 3.5 Discussion and Conclusions; References; 4 Flexible Endoscopy: Optical Molecular Imaging; 4.1 Molecular Imaging for Endoscopic Surveillance of Barrett's Oesophagus; 4.2 The Potential of Fluorescently Labelled Lectins; 4.3 Challenges in Realising the Potential of WGA-IR800 4.4 Materials and Methods4.4.1 Fluorescent Lectin Synthesis; 4.4.2 Endoscope Design; 4.4.3 Image Acquisition and Image Corrections; 4.5 Technical Characterisation; 4.5.1 Methods; 4.5.2 Results; 4.6 Validation Using Biological Samples; 4.6.1 Methods; 4.6.2 Results; 4.7 Discussion and Conclusions; References; 5 Flexible Endoscopy: Multispectral Imaging; 5.1 Multispectral Fluorescence Imaging of Targeted Fluorescent Molecules; 5.2 Multispectral Imaging of Endogenous Contrast; 5.3 Spectrally Resolved Detector Arrays (SRDAs); 5.4 Materials and Methods; 5.4.1 Fluorescent Contrast Agents 5.4.2 Endoscope Design5.4.3 Image Acquisition and Image Corrections; 5.4.4 Spectral Unmixing; 5.5 Multispectral Fluorescence Imaging (MFI); 5.5.1 Methods; 5.5.2 Results; 5.6 Multispectral Reflectance Imaging of Endogenous Tissue Contrast; 5.6.1 Methods; 5.6.2 Results (MuSE 01); 5.7 Discussion and Conclusions; References; 6 Rigid Endoscopy for Intraoperative Imaging of Pituitary Adenoma; 6.1 Pituitary Adenoma; 6.1.1 Standard of Care; 6.1.2 Advanced Imaging of Pituitary Adenoma; 6.2 Endoscope Design; 6.3 Technical Characterisation; 6.3.1 Methods; 6.3.2 Results; 6.4 Clinical Trial; 6.4.1 Method |