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Cyclic-nucleotide phosphodiesterases in the central nervous system : from biology to drug discovery /

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Bibliographic Details
Group Author: Brandon, Nicholas J. (Editor); West, Anthony R., 1970- (Editor)
Published: John Wiley & Sons, Inc.,
Publisher Address: Hoboken, New Jersey :
Publication Dates: [2014]
Literature type: eBook
Language: English
Series: Wiley series in drug discovery and development
Subjects:
Cyclic nucleotide phosphodiesterases.
Central nervous system > physiology.
Nucleotides, Cyclic.
3',5'-Cyclic-AMP Phosphodiesterases > metabolism.
3',5'-Cyclic-AMP Phosphodiesterases > therapeutic use.
Central Nervous System Diseases > drug therapy.
Drug Discovery.
MEDICAL > Physiology.
SCIENCE > Human Anatomy & Physiology. > Human Anatomy & Physiology.
Central nervous system.
Electronic books.
Online Access: http://onlinelibrary.wiley.com/book/10.1002/9781118836507
Carrier Form: 1 online resource (xi, 386 pages) : illustrations (some color).
Bibliography: Includes bibliographical references.
ISBN: 9781118836323
1118836324
9781118836309
1118836308
9781118836538
1118836537
9781118836507
1118836502
047056668X
9780470566688
Index Number: QP370
CLC: R741.05
Contents: Phosphodiesterases and cyclic nucleotide signaling in the CNS / Marco Conti and Wito Richter -- Putting together the pieces of phosphodiesterase distribution patterns in the brain : a jigsaw puzzle of cyclic nucleotide regulation / Michy P. Kelly -- Compartmentalization and regulation of cyclic nucleotide signalling in the CNS / Manuela Zaccolo and Alessandra Stangherlin -- Pharmacological manipulation of cyclic nucleotide phosphodiesterase signaling for the treatment of neurological and psychiatric disorders in the brain / Frank S. Menniti, Niels Plath, Christopher J. Schmidt, and Niels Svenstrup -- Recent results in phosphodiesterase inhibitor development and CNS applications / David P. Rotella -- Crystal structures of phosphodiesterases and implication on discovery of inhibitors / Hengming Ke, Huanchen Wang, Mengchun Ye, and Yingchun Huang -- Inhibition of cyclic nucleotide phosphodiesterases to regulate memory / Han-Ting Zhang, Ying Xu, James O'Donnell -- Emerging role for PDE4 in neuropsychiatric disorders : translating advances from genetic studies into relevant therapeutic strategies / Sandra P. Zoubovsky, Nicholas J. Brandon P, and Akira Sawa -- Beyond erectile dysfunction : understanding PDE5 activity in the central nervous system / Eva P.P. Bollen, Kris Rutten, Olga A.H. Reneerkens, Harry M.W Steinbusch, and Jos Prickaerts -- Molecular and cellular understanding of PDE10A : a dual-substrate phosphodiesterase with therapeutic potential to modulate basal ganglia function / Erik I. Charych and Nicholas J. Brandon -- Role of cyclic nucleotide signaling and phosphodiesterase activation in the modulation of electrophysiological activity of central neurons / Sarah Threlfell and Anthony R. West -- The role of phosphodiesterases in dopamine systems governing motivated behavior / Gretchen L. Snyder, Akinori Nishi, and Joseph P. Hendrick -- Inhibition of phosphodiesterases as a strategy for treatment of spinal cord injury / Elena Nikulina and Marie T. Filbin.

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