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The chemistry and pharmacology of Taxol and its derivatives /

Taxol , a naturally occurring diterpenoid is one of the most exciting antitumor drugs available today. Its current indications (refractory ovarian and metastatic breast cancer) may soon be expanded since the drug is showing activity against lung and head-and-neck cancers. The book opens with a revie...

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Bibliographic Details
Corporate Authors: Elsevier Science & Technology
Group Author: Farina, Vittorio
Published: Elsevier,
Publisher Address: Amsterdam ; New York :
Publication Dates: 1995.
Literature type: eBook
Language: English
Series: Pharmacochemistry library ; v. 22
Subjects:
Paclitaxel
Paclitaxel > Derivatives
Paclitaxel > chemistry
Paclitaxel > pharmacology
Paclitaxel > analogs & derivatives
MEDICAL > Pharmacology
Taxoi den
Farmacologia
Quimica farmaceutica
Drogas
Drugs
Electronic books
Online Access: http://www.sciencedirect.com/science/bookseries/01657208/22
Summary: Taxol , a naturally occurring diterpenoid is one of the most exciting antitumor drugs available today. Its current indications (refractory ovarian and metastatic breast cancer) may soon be expanded since the drug is showing activity against lung and head-and-neck cancers. The book opens with a review of the naturally occurring taxoids, a chapter which is not a comprehensive list of all taxoids isolated to date, but attempts a systematic approact to describing the different classes of taxoids, with particular reference to all skeletal types and the various functionality patterns. Biosynthetic
Carrier Form: 1 online resource (ix, 339 pages) : illustrations.
Bibliography: Includes bibliographical references and index.
ISBN: 9780444817716
0444817719
9780080544991
0080544991
Index Number: RC271
CLC: R979.1
Contents: Naturally occurring taxoids ; The structural elucidation of taxoids / G. Appendino -- Paclitaxel (Taxol ) formulation and prodrug / D. Vyas -- Metabolism and pharmacology of taxoids / M. Wright [and others] -- Paclitaxel (Taxol ) chemistry and structure activity relationships / S.H. Chen, V. Farina -- The chemistry of the Taxol side chain : synthesis, modifications and conformational studies / J. Kant -- The biochemical pharmacology of Taxol and mechanisms of resistance / T. MacDonald, L. Landino.

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