Annual reports in medicinal chemistry. Volume fifty four, Quadruplex nucleic acids as targets for medicinal chemistry /
"The realisation that human, animal, viral and bacterial genomes all contain over-representation of higher-order quadruplex structures in regulatory and other pharmacologically-useful regions, has led to a large number of studies aimed at exploiting this findings for therapeutic and diagnostic...
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Group Author: | |
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Published: |
Elsevier Academic Press,
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Publisher Address: | Amsterdam, The Netherlands : |
Publication Dates: | 2020. |
Literature type: | Book |
Language: | English |
Edition: | First edition. |
Series: |
Annual reports in medicinal chemistry,
volume 54 |
Subjects: | |
Summary: |
"The realisation that human, animal, viral and bacterial genomes all contain over-representation of higher-order quadruplex structures in regulatory and other pharmacologically-useful regions, has led to a large number of studies aimed at exploiting this findings for therapeutic and diagnostic purposes. Quadruplex-binding small molecules are starting to be evaluated in human clinical trials."--publisher's web page, viewed August 26, 2020. |
Carrier Form: | xviii, 546 pages : illustrations (some color) ; 24 cm. |
Bibliography: | Includes bibliographical references. |
ISBN: | 9780128210178 |
Index Number: | QP625 |
CLC: | R914-54 |
Call Number: | R914-54/A512/v.54 |
Contents: | Intro -- Quadruplex Nucleic Acids As Targets For Medicinal Chemistry -- Copyright -- Contents -- Contributors -- Preface -- Foreword -- References -- Part 1: Fundamentals of quadruplexes and their biology -- Chapter One: Fundamentals of G-quadruplex biology -- 1. Introduction -- 2. Experimental approaches to G-quadruplex biology -- 2.1. Some general principles and potential pitfalls -- 2.2. In silico approaches -- 2.3. Antibodies -- 2.4. Chromatin immunoprecipitation -- 2.5. Small molecules -- 2.6. Microscopy -- 2.7. Genetic approaches -- 3. Biological processes impacted by G-quadruplexes |