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Evaluation of drug candidates for preclinical development pharmacokinetics, metabolism, pharmaceutics, and toxicology /

Explaining the assessment of potential drug compounds, this is an ideal introductory reference for those new to drug discovery. It includes sections on pharmacokinetics and drug metabolism, integration of pharmaceutical development, and predictive safety assessment. Topics include: cost analysis, dr...

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Bibliographic Details
Corporate Authors: Wiley InterScience Online service
Group Author: Han, Chao; Davis, Charles B. Charles Baldwin; Wang, Binghe, 1962
Published:
Literature type: Electronic eBook
Language: English
Series: Wiley series in drug discovery and development
Subjects:
Drug development
Pharmacokinetics
Drugs > Metabolism
Drug Evaluation, Preclinical
Drug Discovery
Drug Industry > standards
Pharmaceutical Preparations > metabolism
Pharmacology > methods
MEDICAL > Drug Guides
MEDICAL > Pharmacology
MEDICAL > Pharmacy
MEDICAL > Nursing > Pharmacology
Electronic books
Online Access: http://onlinelibrary.wiley.com/book/10.1002/9780470574898
Summary: Explaining the assessment of potential drug compounds, this is an ideal introductory reference for those new to drug discovery. It includes sections on pharmacokinetics and drug metabolism, integration of pharmaceutical development, and predictive safety assessment. Topics include: cost analysis, drug transporters, cytochrome P-450 and drug-drug interactions, plasma protein binding, assessing stability, ways to optimize drug formulation, toxicology and toxicokinetics, and more. Readers will understand why absorption-distribution-metabolism-excretion-toxicology (ADMET) is key in drug developm
Item Description: Includes index.
Carrier Form: 1 online resource.
Bibliography: Includes bibliographical references and index.
ISBN: 9780470574898
0470574895
9780470574881 (electronic bk.)
0470574887 (electronic bk.)
1282684906
9781282684904
Index Number: RM301
CLC: R915
Contents: Pharmacokinetics in preclinical drug development : an overview / Dion Brocks -- The role of membrane transporters in drug disposition / Fanfan Zhou, Peng Duan, and Guofeng You -- Cytochrome P450 : structure, function, and application in drug discovery and development / Ramesh B. Bambal and Stephen E. Clarke -- The role of drug metabolism and metabolite identification in drug discovery / Xiangming Guan -- Protein binding in drug discovery and development / Vikram Ramanathan and Nimish Vachharajani -- Prediction of the pharmacokinetics in humans / Chao Han and Remash Bambal -- Pharmaceutics de

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