Screen LibraryFragment-based drug discovery and X-ray crystallography
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| Group Author: | ; ; |
|---|---|
| Published: |
Springer,
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| Publisher Address: | Heidelberg New York |
| Publication Dates: | c2012. |
| Literature type: | Book |
| Language: | English |
| Series: |
Topics in current chemistry ; 317 |
| Subjects: | |
| Carrier Form: | xi, 225 p.: ill. (some col.) ; 24 cm. |
| ISBN: |
9783642275395 (alk. paper) 3642275397 (alk. paper) |
| Index Number: | R914 |
| CLC: | R914.2 |
| Call Number: | R914.2/F811-1 |
| Contents: |
Includes bibliographical references and index. Introduction to fragment-based drug discovery - Fragment screening using x-ray crystallography -- Hsp90 inhibitors and drugs from fragment and virtual screening -- Combining NMR and x-ray crystallography in fragment-based drug discovery: discovery of highly potent and selective BACE-1 inhibitors -- Combining biophysical screening and x-ray crystallography for fragment-based drug discovery -- Targeting protein-protein interactions and fragment-based drug discovery -- Fragment screening and HIV therapeutics -- Fragment-based approaches and computer-aided drug discovery. |