Screen LibraryTargeting cell survival pathways to enhance response to chemotherapy /
"Targeting Cell Survival Pathways to Enhance Response to Chemotherapy encompasses recently developed molecular targeting agents and approaches that suppress cell survival signaling. Cell survival signaling attenuates the effectiveness of conventional chemotherapy and numerous mechanisms have be...
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| Group Author: | |
|---|---|
| Published: |
Elsevier/Academic Press,
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| Publisher Address: | London, United Kingdom : |
| Publication Dates: | [2018] |
| Literature type: | Book |
| Language: | English |
| Series: |
Cancer sensitizing agents for chemotherapy,
volume 3 |
| Subjects: | |
| Summary: |
"Targeting Cell Survival Pathways to Enhance Response to Chemotherapy encompasses recently developed molecular targeting agents and approaches that suppress cell survival signaling. Cell survival signaling attenuates the effectiveness of conventional chemotherapy and numerous mechanisms have been described, and continue to be described, which contribute to cell survival in the face of chemotherapy treatment. Key pathways leading to chemoresistance emanate from growth factor receptors, PI3K, STAT3, anti-apoptotic Bcl-2 family members, autophagy, and the DNA damage response pathway. New advanc |
| Carrier Form: | xvi, 292 pages : color illustrations ; 25 cm. |
| Bibliography: | Includes bibliographical references and index. |
| ISBN: |
9780128164327 0128164328 |
| Index Number: | RC271 |
| CLC: | R730.53 |
| Call Number: | R730.53/T185-4 |
| Contents: |
Targeting members of the epidermal growth factor receptor family to improve response to chemotherapy / Targeting the hepatocyte growth factor receptor to overcome resistance to targeted therapies / Roles for AXL and MERTK in resistance to cytotoxic and targeted therapies / The JNK pathway in drug resistance / |