Screen LibraryMechanisms of genome protection and repair /
This volume is about DNA damage and repair. It covers recent advances in several important research areas of this rapidly expanding field, and does so at several levels, from individual molecules to organisms. The topics include mechanisms of damage recognition by DNA repair enzymes, chromatin respo...
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| Group Author: | |
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| Published: |
Springer,
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| Publisher Address: | Cham, Switzerland : |
| Publication Dates: | [2020] |
| Literature type: | Book |
| Language: | English |
| Series: |
Advances in experimental medicine and biology,
volume1241 |
| Subjects: | |
| Summary: |
This volume is about DNA damage and repair. It covers recent advances in several important research areas of this rapidly expanding field, and does so at several levels, from individual molecules to organisms. The topics include mechanisms of damage recognition by DNA repair enzymes, chromatin response to DNA damage, special ways of mutagenesis, biomarkers of genotoxicity, and the integrated organism response to genotoxic and other kinds of stress. The book starts with two chapters about structural and mechanistic features of protein-DNA interactions that ensure fast and reliable discriminat |
| Carrier Form: | xvi, 220 pages : illustrations (some color), forms ; 26 cm. |
| Bibliography: | Includes bibliographical references and index. |
| ISBN: |
9783030412821 (hardcover) : 3030412822 (hardcover) 9783030412838 (ebook) 3030412830 (ebook) |
| Index Number: | QH467 |
| CLC: | Q754 |
| Call Number: | Q754/M486 |
| Contents: | Preface -- Kinetic Milestones of Damage Recognition by DNA Glycosylases of the Helix-Hairpin-Helix Structural Superfamily -- Protein Engineering of DNA-Dependent Enzymes -- A Multifunctional Protein PolDIP2 in DNA Translesion Synthesis -- Impact of PARP1, PARP2 and PARP3 on the Base Excision Repair of Nucleosomal DNA -- Base Excision Repair in Chromatin and the Requirement for Chromatin Remodelling -- DNA Repair and Mutagenesis in Vertebrate Mitochondria: Evidence for Asymmetric DNA Strand Inheritance -- Mystery of Expansion: DNA Metabolism and Unstable Repeats -- The Detection of 8-Oxo-7,8- |