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Hepatitis B virus : molecular mechanisms in disease and novelstrategies for therapy /

The book covers both the molecular aspects of hepatitis B virus replication and gene expression in vivo and in model systems, and the clinical impact of genetic variants or immunological response in chronic infection. Major emphasis is laid on the molecular mechanisms underlying hepatitis B virus-as...

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Bibliographic Details
Corporate Authors: World Scientific (Firm)
Group Author: Koshy, Rajen. (Editor); Caselmann, Wolfgang H. (Editor)
Published: Imperial College Press ; Distributed by World Scientific Pub. Co.,
Publisher Address: London : Singapore :
Publication Dates: 1998.
Literature type: eBook
Language: English
Subjects:
Hepatitis B virus.
Hepatitis B.
Electronic books.
Online Access: http://www.worldscientific.com/worldscibooks/10.1142/P005#t=toc
Summary: The book covers both the molecular aspects of hepatitis B virus replication and gene expression in vivo and in model systems, and the clinical impact of genetic variants or immunological response in chronic infection. Major emphasis is laid on the molecular mechanisms underlying hepatitis B virus-associated liver carcinogenesis and their possible relevance to therapy and to the prevention of infection. Rational approaches to design novel vaccines or cytokine treatments, as well as strategies to develop vectors for liver-directed gene therapy, are discussed.
Carrier Form: 1 online resource (viii,328pages) : illustrations
Bibliography: Includes bibliographical references and indexes.
ISBN: 9781848161078
Index Number: QR201
CLC: R512.6
Contents: I. Molecular biology of Hepatitis B virus. ch. 1. Replication of the Hepatitis B virus genome / Christoph Seeger and William S. Mason -- ch. 2. The regulation of Hepatitis B virus gene expression: an overview of the cis- and trans-acting components / Marshall J. Kosovsky, Ishtiaq Qadri and Aleem Siddiqui -- ch. 3. Animal models and experimental systems in Hepatitis B virus research / Stephan Schaefer, Tanja Tolle, Stefan Lottmann and Wolfram H. Gerlich -- II. Infection and chronic disease. ch. 4. Natural course of HBV infection / Hubert E. Blum, Stefan Wieland, Eike Walter, Fritz von Weizsacker, Wolf-Bernhard Offensperger and Darius Moradpour -- ch. 5. Genetic variants of HBV / Tim J. Harrison -- ch. 6. The immunology of chronic Hepatitis B / Barbara Rehermann and Francis V. Chisari -- III. Hepatocellular carcinoma. ch. 7. HBV DNA integration and insertional mutagenesis / Katsuro Koike -- ch. 8. Transactivators of HBV, signal transduction and tumorigenesis / Wolfgang H. Caselmann and Rajen Koshy -- ch. 9. Oncogenes, tumour suppressors and co-factors in hepatocellular carcinoma / Hisaki Nagai and Marie Annick Buendia -- IV. Rational approaches for the prevention of infection and therapy. ch. 10. Hepatitis B virus vaccines / Florian Schodel -- ch. 11. Chronic Hepatitis B viral infection: cytokines and therapy / Graham R. Foster and Howard C. Thomas -- ch. 12. The development of targettable vectors for the liver and prospects for treatment / Ludwig Weiss and Peter Hans Hofschneider.

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